Osmosis Jones poster
Where to stream

Osmosis Jones

6.520011h 35mPGMovieActionAdventureAnimation

A white blood cell policeman, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.

DirectorsBobby Farrelly·Peter Farrelly
WriterMarc Hyman
ProducersBobby Farrelly·Zak Penn

Where to watch

Amazon Prime VideoAmazon Prime VideoAmazon Prime Video with AdsAmazon Prime Video with AdsHowdy Amazon ChannelHowdy Amazon ChannelHooplaHooplaThe Roku ChannelThe Roku ChannelYouTube FreeYouTube FreeTubi TVTubi TV
Availability shown for United States · rights vary by country

Cast · Directed by Bobby Farrelly

CRChris Rock
Chris Rock
Osmosis Jones (voice)
LFLaurence Fishburne
Laurence Fishburne
Thrax (voice)
DPDavid Hyde Pierce
David Hyde Pierce
Drix (voice)
BNBrandy Norwood
Brandy Norwood
Leah (voice)
BMBill Murray
Bill Murray
Frank Detorre
EFElena Franklin
Elena Franklin
Shane Detorre
WSWilliam Shatner
William Shatner
Mayor Phlegmming (voice)
RHRon Howard
Ron Howard
Tom Colonic (voice)
KRKid Rock
Kid Rock
Kidney Rock (voice)
MSMolly Shannon
Molly Shannon
Mrs. Boyd
CEChris Elliott
Chris Elliott
Bob
JAJonathan Adams
Jonathan Adams
Officer Tom (voice)

More from Bobby Farrelly · Director

Trailer Park Boys
Trailer Park Boys
2001 · 7.8
There's Something About Mary
There's Something About Mary
1998 · 6.6
Dumb and Dumber To
Dumb and Dumber To
2014 · 5.6
Me, Myself & Irene
Me, Myself & Irene
2000 · 6.6
Shallow Hal
Shallow Hal
2001 · 6.2
Hall Pass
Hall Pass
2011 · 5.8
The Three Stooges
The Three Stooges
2012 · 5.8
Champions
Champions
2023 · 6.7
The Heartbreak Kid
The Heartbreak Kid
2007 · 5.8
The Now
The Now
2021 · 5.8
See all fromBobby Farrelly

More like this

LEGO DC Comics Super Heroes: The Flash
LEGO DC Comics Super Heroes: The Flash
2018 · 6.8
Chickenhare and the Hamster of Darkness
Chickenhare and the Hamster of Darkness
2022 · 7.2
The Willoughbys
The Willoughbys
2020 · 7.1
LEGO Marvel Avengers: Mission Demolition
LEGO Marvel Avengers: Mission Demolition
2024 · 6.5
Invader Zim: Enter the Florpus
Invader Zim: Enter the Florpus
2019 · 7.4
Jimmy Timmy Power Hour
Jimmy Timmy Power Hour
2004 · 7.1
Phineas and Ferb: Mission Marvel
Phineas and Ferb: Mission Marvel
2013 · 6.6
Batman: Return of the Caped Crusaders
Batman: Return of the Caped Crusaders
2016 · 6.5
Regular Show: The Movie
Regular Show: The Movie
2015 · 7.9
Phineas and Ferb: Star Wars
Phineas and Ferb: Star Wars
2014 · 7.1
Leroy & Stitch
Leroy & Stitch
2006 · 6.5
Arctic Dogs
Arctic Dogs
2019 · 5.9

Osmosis Jones — streaming FAQ

Which OTT platform streams Osmosis Jones?

Osmosis Jones is streaming on Amazon Prime Video, Howdy and Hoopla in United States, and available to rent or buy on Amazon Video and Apple TV Store. It's not currently on Netflix.

Is Osmosis Jones on Netflix?

No, Osmosis Jones is not on Netflix in United States as of November 2026. It's currently on Amazon Prime Video and Howdy.

Is Osmosis Jones on Amazon Prime Video?

Yes — Osmosis Jones is included with an Amazon Prime Video subscription in United States as of November 2026.

Where can I watch Osmosis Jones for free?

Osmosis Jones is available to stream free (with ads) on Hoopla and The Roku Channel in United States.